ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of the compound Chinese traditional drug Xianling Gubao Capsule on the semen quality of infertile males.</p><p><b>METHODS</b>We treated 66 infertile men with Xianling Gubao Capsule for 24 months, and analyzed the semen quality and sperm morphology before and after the treatment.</p><p><b>RESULTS</b>Two months after the medication, sperm concentration was increased by a small margin, but no statistically significant changes were observed in sperm vitality and motility (P > 0.05), the rate of morphologically normal sperm was significantly raised from 25.8% before treatment to 57.6% (P < 0.05) in those with the normal rate > or = 15%, but decreased from 53.0% to 25.8% (P < 0.05) in those with the normal rate < 9%. Among the 7 cases of oligospermia, the rate of morphologically normal sperm was elevated to an average of 10.9% after the 4-month medication, significantly different from the baseline rate of 5.8% (P < 0.05). Five spontaneous pregnancies and 1 successful IVF-ICSI were achieved during the treatment.</p><p><b>CONCLUSION</b>Xianling Gubao Capsule can improve semen quality and significantly increase the percentage of morphologically normal sperm.</p>